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LEADING NITRIC OXIDE RESEARCH
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Leadership

Nathan S. Bryan, Ph.D.
(Chief Science Officer)

Dr. Nathan S. Bryan is an Assistant Professor of Molecular Medicine within the Brown Foundation Institute of Molecular Medicine, part of the School of Medicine at the University of Texas Health Science Center at Houston. 
He is also on faculty within the Department of Integrative Biology and Pharmacology and Graduate School of Biomedical Sciences at the UT Houston Medical School.

Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research.  He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute.

Dr. Bryan joined the Institute of Molecular Medicine, University of Texas Health Science Center in Houston, in June 2006 and is now part of the Texas Therapeutics Institute (TTI).  TTI’s mission is to carry out translational research and drug discoveries related to cancer, cardiovascular disease and stem cells.  He is an active member of the Nitric Oxide Society, Society for Free Radical Biology and Medicine, American Heart Association, American Diabetes Association and American Physiological Society.

Dr. Bryan's Research Philosophy

Dr. Bryan's research is dedicated to providing a better understanding of the interactions of nitric oxide and related metabolites with their different biological targets at the molecular and cellular level and the significance of these reactions for physiology and patho-physiology. Attempts are made to identify what particular changes in N-O-related signaling pathways and reaction products occur in disease states such as endothelial dysfunction, ischemia/reperfusion, tissue/cardiac protection, diabetes, atherosclerosis and inflammation with the aim of testing their amenability as biomarkers for diagnosis and/or treatment of specific disease.

Current research is directed to understand the interactions of exogenous dietary nitrite/nitrate (NOx) on the endogenous NO/cGMP pathway and how perturbations in each system affect cardiovascular health.

Dr. Bryan is credited with several seminal discoveries in the nitric oxide field:

  1. Nitrite is a signaling molecule and regulator of gene expression. [1]
  2. Nitrite and nitrate are indispensable nutrients required for optimal cardiovascular health. [2]
  3. First to describe nitrite and nitrate as vitamins. [3]
  4. Discovered an endocrine function of nitric oxide. [4]
  5. Discovered natural product chemistry that can be used to safely and effectively generate and restore nitric oxide in humans. [5, 6]

Dr. Bryan's Findings

These discoveries and findings have unveiled many beneficial effects of nitrite in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in diseases associated with N-O insufficiency and new guidelines for optimal health.

Dr. Bryan has published a number of highly cited papers and authored or edited 4 books.

[1] Bryan NS (Editor):  Food, Nutrition and the Nitric Oxide Pathway. DesTech Publishing – Pennsylvania ISBN: 978-1-932078-84-8, September 2009

[2] Bryan NS and Loscalzo J (Editors) Nitrite and Nitrate in Human Health and Disease – Springer Humana Press New York ISBN:  978-1-60761-615-3, May 2011

[3] Nathan S. Bryan & Janet Zand with Bill Gottlieb:  The Nitric Oxide (NO) Solution Good for you Books Publishing – ISBN: 978-0-615-41713-4; November 2010

[4] Nathan S. Bryan & Caroline Pierini:  Beet the Odds – ISBN: 978-1-9888135-0-2; 2013

Leading Nitric Oxide Researcher

He has three issued US patents and 6 pending worldwide.  Dr. Bryan is also the co-founder and Chief Science Officer of Neogenis Labs, a Texas based company started to commercialize nitric oxide based technologies and diagnostics.

  1. Bryan, N.S., et al., Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol, 2005. 1(5): p. 290-7.
  2. Hord, N.G., Y. Tang, and N.S. Bryan, Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr, 2009. 90(1): p. 1-10.
  3. Bryan, N.S., Cardioprotective actions of nitrite therapy and dietary considerations. Front Biosci, 2009. 14: p. 4793-808.
  4. Elrod, J.W., et al., Nitric oxide promotes distant organ protection:  Evidence for an endocrine role of nitric oxide. Proc Natl Acad Sci U S A, 2008. 105(32): p. 11430-11435.
  5. Nagamani, S.C., et al., Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet, 2012. 90(5): p. 836-46.
  6. Zand, J., et al., All-natural nitrite and nitrate containing dietary supplement promotes nitric oxide production and reduces triglycerides in humans. Nutr Res, 2011. 31(4): p. 262-9.
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